《英文msh詞典》Factor VIIIR-RCo
[入口詞] Factor VIIIR-RCo
[主題詞] von Willebrand Factor
[英文釋義] A high-molecular-weight plasma protein,produced by endothelial cells and megakaryocytes,that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen,platelets,and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in von Willebrand's disease is due to the deficiency of this factor.